Document Report Card

ID: ALA1156786

Journal: J Med Chem

Title: Conformationally constrained mimetics of laminin peptide YIGSR as precursors for antimetastatic disintegrins.

Authors: Bella A, Lewis H, Phu J, Bottrill AR, Mistry SC, Pullar CE, Ryadnov MG.

Abstract: Conformationally constrained mimetics of the laminin cell-adhesion site, YIGSR, are described. The site is the natural antagonist of the integrin-associated laminin receptor 1 (LAMR1) known to mediate metastatic tumor adhesion. The attachment of selected metastatic cell lines toward the constrained antagonists has been assessed. Observed differential responses prompted by folding preferences of the mimetics revealed stronger attachment activities for turnlike structures. The results permit the conformational design of antimetastatic disintegrins.

CiteXplore: 19950927

DOI: 10.1021/jm901212n