2,5-Disubstituted pyridines as potent GPR119 agonists.

ID: ALA1156968

Journal: Bioorg Med Chem Lett

Title: 2,5-Disubstituted pyridines as potent GPR119 agonists.

Authors: Wu Y, Kuntz JD, Carpenter AJ, Fang J, Sauls HR, Gomez DJ, Ammala C, Xu Y, Hart S, Tadepalli S.

Abstract: A series of 2-piperazinyl-5-alkoxypyridines were synthesized and screened against human GPR119 receptor. Through SAR analysis, compounds containing 2-alkylsulfonylpiperazinyl-5-alkoxypyridines were discovered and found to be potent agonists of the human GPR119 receptor.

CiteXplore: 20227877

DOI: 10.1016/j.bmcl.2010.02.083

Patent ID: ┄