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ID: ALA1156969

Journal: Bioorg Med Chem Lett

Title: Synthesis of substituted N-[3-(3-methoxyphenyl)propyl] amides as highly potent MT(2)-selective melatonin ligands.

Authors: Hu Y, Ho MK, Chan KH, New DC, Wong YH.

Abstract: A series of substituted N-[3-(3-methoxyphenyl)propyl] amides were synthesized and their binding affinities towards human melatonin MT(1) and MT(2) receptors were evaluated. It was discovered that a benzyloxyl substituent incorporated at C6 position of the 3-methoxyphenyl ring dramatically enhanced the MT(2) binding affinity and at the same time decreased MT(1) binding affinity.

CiteXplore: 20227878

DOI: 10.1016/j.bmcl.2010.02.084