Aminofurazans as potent inhibitors of AKT kinase.

ID: ALA1157000

Journal: Bioorg Med Chem Lett

Title: Aminofurazans as potent inhibitors of AKT kinase.

Authors: Rouse MB, Seefeld MA, Leber JD, McNulty KC, Sun L, Miller WH, Zhang S, Minthorn EA, Concha NO, Choudhry AE, Schaber MD, Heerding DA.

Abstract: AKT inhibitors containing an imidazopyridine aminofurazan scaffold have been optimized. We have previously disclosed identification of the AKT inhibitor GSK690693, which has been evaluated in clinical trials in cancer patients. Herein we describe recent efforts focusing on investigating a distinct region of this scaffold that have afforded compounds (30 and 32) with comparable activity profiles to that of GSK690693.

CiteXplore: 19179070

DOI: 10.1016/j.bmcl.2009.01.002

Patent ID: ┄