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ID: ALA1157048
Journal: Eur J Med Chem
Title: Synthesis and in vitro activity of limonene derivatives against Leishmania and Trypanosoma.
Authors: Graebin CS, Madeira Mde F, Yokoyama-Yasunaka JK, Miguel DC, Uliana SR, Benitez D, Cerecetto H, González M, Rosa RG, Eifler-Lima VL.
Abstract: The synthesis and in vitro activity of R(+)-Limonene derivatives against Leishmania and Trypanosoma cruzi strains are reported. Seven compounds have shown better in vitro activity against Leishmania (V.)braziliensis than the standard drug pentamidine. Additionally, we have identified two promising new anti-T. cruzi limonene derivatives.
CiteXplore: 20116908