Synthesis and study of some new 1,3-isoindoledione derivatives as potential antibacterial agents.
Basic Information
ID: ALA1157049
Journal: Eur J Med Chem
Title: Synthesis and study of some new 1,3-isoindoledione derivatives as potential antibacterial agents.
Authors: Khalil AM, Berghot MA, Gouda MA.
Abstract: In an effort to establish new candidates with improved antibacterial activities, we reported here the synthesis and in vitro antibacterial evaluation of various series of 2-substituted-3a,4,9,9a-tetrahydro-4,9-benzeno-benz[f]isoindole-1,3-diones: 4-acetyl-phenyl 2, 2,2-dibromoacetylphenyl 3, benzimidazole 4, acetylbenzimidazole 5, aminophenyl 6, acetamide 7, naphthalene 8, disulfide 9, mercaptophenyl 10, hydroxyphenyl 11, phenyl ester 12, triazole 13, benzothiophene 14, benzothiazole 15 phenylazo 16a, b and aminomethane 17 derivatives. The newly synthesized compounds were characterized by (IR, (1)H NMR, (13)C NMR and mass spectrum studies). Representative compounds of the synthesized products were established and evaluated as antibacterial agents.
CiteXplore: 20117862
DOI: 10.1016/j.ejmech.2009.12.064
Patent ID: ┄