Document Report Card

ID: ALA1157061

Journal: J Nat Prod

Title: Polybioside, a neuroactive compound from the venom of the social wasp Polybia paulista.

Authors: Saidemberg DM, da Silva-Filho LC, Tognoli LM, Tormena CF, Palma MS.

Abstract: Polybioside (1) was isolated from the venom of the social wasp Polybia paulista, and its structure was assigned as 3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl 3-(1H-imidazol-4-yl)propanimidate by NMR and MS protocols. The application of polybioside in rat brain, followed by the detection of c-Fos protein expression in some brain regions, indicated the compound is neuroactive in a number of brain areas. Polybioside causes convulsions in rats, even when peripherally applied.

CiteXplore: 20158240

DOI: 10.1021/np900424t