Document Report Card

ID: ALA1157262

Journal: J Nat Prod

Title: A pyrimidine-beta-carboline and other alkaloids from Annona foetida with antileishmanial activity.

Authors: Costa EV, Pinheiro ML, Xavier CM, Silva JR, Amaral AC, Souza AD, Barison A, Campos FR, Ferreira AG, Machado GM, Leon LL.

Abstract: Bioassay-guided fractionation of the bark extract of Annona foetida afforded a new antileishmanial pyrimidine-beta-carboline alkaloid, N-hydroxyannomontine (1), together with the previously reported annomontine (2), O-methylmoschatoline (3), and liriodenine (4). The structure of compound 1 was established on the basis of extensive 1D and 2D NMR and MS analyses. This is the third reported pyrimidine-beta-carboline-type alkaloid and is particularly important for Annona genus chemotaxonomy. In addition, all compounds exhibit in vitro antileishmanial activity against promastigote forms of Leishmania braziliensis. Compounds 2 and 4 showed better activity than compounds 1 and 3 against L. braziliensis. Compound 2 was not active against L. guyanensis.

CiteXplore: 16499336

DOI: 10.1021/np050422s