Document Report Card

ID: ALA1157292

Journal: J Nat Prod

Title: (+)-agelasine D: improved synthesis and evaluation of antibacterial and cytotoxic activities.

Authors: Vik A, Hedner E, Charnock C, Samuelsen O, Larsson R, Gundersen LL, Bohlin L.

Abstract: An improved synthesis of (+)-agelasine D (10) from (+)-manool is reported together with cytotoxic and antibacterial data for agelasine D and structurally close synthetic analogues. These compounds display a broad spectrum of antibacterial activities including effects on M. tuberculosis and Gram-positive and Gram-negative bacteria (both aerobes and anaerobes). They exhibit profound cytotoxic activity against several cancer cells, including a multidrug-resistant cell line. (+)-Agelasine D (10) has been isolated earlier from a marine sponge (Agelas sp.).

CiteXplore: 16562840

DOI: 10.1021/np050424c