Document Report Card

ID: ALA1157323

Journal: J Nat Prod

Title: Chloriolide, a 12-membered macrolide from Chloridium virescens var. chlamydosporum (NRRL 37636).

Authors: Jiao P, Swenson DC, Gloer JB, Wicklow DT.

Abstract: A new 12-membered macrolide (chloriolide; 1) was obtained from solid-substrate fermentation cultures of Chloridium virescens var. chlamydosporum that was originally isolated from decayed wood. The structure of 1 was determined by analysis of 1D NMR, 2D NMR, and MS data and confirmed by X-ray crystallographic analysis. The absolute configuration of 1 was assigned by application of the modified Mosher method using the (R)- and (S)-MTPA derivatives of a rearrangement product obtained under standard acylation conditions. The assignment made by analysis of the corresponding Deltadelta values was verified by X-ray crystallographic analysis of the (S)-MTPA derivative.

CiteXplore: 16643041

DOI: 10.1021/np0504964