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ID: ALA1157446

Journal: Bioorg Med Chem Lett

Title: Cubyl amides: novel P2X7 receptor antagonists.

Authors: Gunosewoyo H, Guo JL, Bennett MR, Coster MJ, Kassiou M.

Abstract: Polycyclic amides 2 and 5-9 were successfully synthesised and their lipophilicity profiles were evaluated using reverse-phase HPLC. All synthesised compounds possessed P2X7R antagonistic properties when tested on rat spinal cord microglia cells. Extensive screening for binding to other neuroreceptor subtypes demonstrated their P2X7 selectivity.

CiteXplore: 18524586

DOI: 10.1016/j.bmcl.2008.05.062