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ID: ALA1157446
Journal: Bioorg Med Chem Lett
Title: Cubyl amides: novel P2X7 receptor antagonists.
Authors: Gunosewoyo H, Guo JL, Bennett MR, Coster MJ, Kassiou M.
Abstract: Polycyclic amides 2 and 5-9 were successfully synthesised and their lipophilicity profiles were evaluated using reverse-phase HPLC. All synthesised compounds possessed P2X7R antagonistic properties when tested on rat spinal cord microglia cells. Extensive screening for binding to other neuroreceptor subtypes demonstrated their P2X7 selectivity.
CiteXplore: 18524586