Document Report Card
Basic Information
ID: ALA1157493
Journal: Bioorg Med Chem Lett
Title: Synthesis and screening of small molecule inhibitors of anthrax edema factor.
Authors: Jimenez ME, Bush K, Pawlik J, Sower L, Peterson JW, Gilbertson SR.
Abstract: The synthesis and development of a novel class of molecules that inhibit anthrax edema factor, an adenylyl cyclase, is reported. These molecules are derived from the initial discovery that histidine and imidazole adducts of the prostaglandin PGE(2) reduce the net secretory response of cholera toxin-challenged mice and act directly on the action of anthrax edema factor, a calmodulin-dependent adenylyl cyclase. The simple enones examined in this letter were prepared by palladium-catalyzed Suzuki reaction.
CiteXplore: 18539457