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ID: ALA1157758
Journal: Bioorg Med Chem Lett
Title: Structural and stereochemical requirements of the spiroketal group of hippuristanol for antiproliferative activity.
Authors: Li W, Dang Y, Liu JO, Yu B.
Abstract: Hippuristanol is a natural product that has recently been shown to inhibit eukaryotic translation initiation and tumor cell proliferation. To investigate the structure and activity relationship of hippuristanol, we synthesized a series of analogs by expanding the size of its F ring and determined their effects on the proliferation of cancer cell lines. All changes to the F-ring of hippuristanol resulted in 3-fold to >100-fold decrease in activity.
CiteXplore: 20409710