Document Report Card

ID: ALA1157777

Journal: J Med Chem

Title: Identification of hits as matrix-2 protein inhibitors through the focused screening of a small primary amine library.

Authors: Hu W, Zeng S, Li C, Jie Y, Li Z, Chen L.

Abstract: Although amantadine derivatives are the only M2 drugs for influenza virus A, their use is limited in the U.S. because of drug resistance. Here we report the identification of multiple M2 inhibitors that were rapidly generated through focused screening of a small primary amine library that was designed using a scaffold-hopping strategy based on amantadine. These compounds are as active as amantadine and might be hits for further lead generation processes.

CiteXplore: 20394375

DOI: 10.1021/jm901664a