Antitumor activity and COMPARE analysis of bis-indole derivatives.
Basic Information
ID: ALA1157784
Journal: Bioorg Med Chem
Title: Antitumor activity and COMPARE analysis of bis-indole derivatives.
Authors: Andreani A, Burnelli S, Granaiola M, Leoni A, Locatelli A, Morigi R, Rambaldi M, Varoli L, Landi L, Prata C, Dalla Sega FV, Caliceti C, Shoemaker RH.
Abstract: This paper reports the synthesis of new derivatives (formed by two indole systems separated by a central moiety) analogous of potent antitumor agents previously described. The activity of the bis-indoles bearing a pyridine core confirms the good result described in the previous paper and compound 4c was chosen for the first in vivo experiment (Hollow Fiber Assay). COMPARE analysis and structure-activity relationships were also considered. Contrary to data reported by other Authors, no correlations were found between antitumor activity and NQO1 induction.
CiteXplore: 20395150
DOI: 10.1016/j.bmc.2010.03.063
Patent ID: ┄