Basic Information
ID: ALA1157807
Journal: Bioorg Med Chem
Title: NO-releasing esters show carbonic anhydrase inhibitory action against human isoforms I and II.
Authors: Ekinci D, Cavdar H, Talaz O, Sentürk M, Supuran CT.
Abstract: Carbonic anhydrase (CA, EC 4.2.1.1) inhibitors (CAIs) are a class of pharmaceuticals used as antiglaucoma agents, diuretics, antiepileptics, in the management of mountain sickness, gastric and duodenal ulcers, neurological disorders, or osteoporosis. We report here the inhibitory capacities of some organic nitrates against two human (hCA) isozymes, hCA I and hCA II. The IC(50) values of compounds 1-12 against hCA I ranged between 7.13mM and 124mM, and against hCA II between 65.1microM and 0.79mM. Nitrate esters are thus interesting hCA I and II inhibitors, and might be used as leads for generating enzyme inhibitors eventually targeting other isoforms which have not been assayed yet for their interactions with such agents.
CiteXplore: 20430631
DOI: 10.1016/j.bmc.2010.03.082
Patent ID: ┄
Associated Items: Associated Bioactivities Associated Assays Associated Compounds Associated Targets