Bioactivity-guided isolation of mosquitocidal constituents from the rhizomes of Plumbago capensis Thunb.
Basic Information
ID: ALA1157890
Journal: Bioorg Med Chem Lett
Title: Bioactivity-guided isolation of mosquitocidal constituents from the rhizomes of Plumbago capensis Thunb.
Authors: Sreelatha T, Hymavathi A, Murthy JM, Rani PU, Rao JM, Babu KS.
Abstract: A bioassay-guided fractionation and chemical examination of chloroform extract of Plumbago capensis roots resulted in isolation and characterization of two new napthaquinone derivatives (4, 8) along with six known compounds (1-3, 5-7). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 1D and 2D NMR) data analysis and by comparison with the literature data. All the compounds were tested for their mosquito larvicidal activity against fourth instar larvae of Aedes aegypti, and compared with that of rotenone. Among the tested compounds, isoshinanolone (3) and plumbagin (1) showed excellent toxicity with LC(50) values of 1.26 and 5.43 microg/mL. New compound (8) displayed moderate toxicity against the tested mosquito species.
CiteXplore: 20347303
DOI: 10.1016/j.bmcl.2010.02.107
Patent ID: ┄