Document Report Card
Basic Information
ID: ALA1157906
Journal: Bioorg Med Chem Lett
Title: Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2.
Authors: Nolan KA, Humphries MP, Bryce RA, Stratford IJ.
Abstract: The purpose of the work was to identify novel inhibitors of the enzyme NQO2. Using computational molecular modelling, a QSAR (R(2)=0.88) was established, relating inhibitory potency with calculated binding affinity. From this, the imidazoacridin-6-one, NSC660841, was identified as the most potent inhibitor of NQO2 yet reported (IC(50)=6 nM).
CiteXplore: 20356739