Discovery and structural optimization of pyrazole derivatives as novel inhibitors of Cdc25B.

ID: ALA1157928

Journal: Bioorg Med Chem Lett

Title: Discovery and structural optimization of pyrazole derivatives as novel inhibitors of Cdc25B.

Authors: Chen HJ, Liu Y, Wang LN, Shen Q, Li J, Nan FJ.

Abstract: Structural optimization and preliminary structure-activity relationship studies of a series of N-substituted maleimide fused-pyrazole analogues with Cdc25B inhibitory activity, starting from a high-throughput screening hit, are illustrated. A simplified 3,5-diacyl pyrazole analogue was obtained as the most potent compound (118, IC(50)=0.12 microM) with a 270-fold increase in potency.

CiteXplore: 20363629

DOI: 10.1016/j.bmcl.2010.03.040

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