Document Report Card

ID: ALA1157943

Journal: J Nat Prod

Title: Oblongifolins A-D, polyprenylated benzoylphloroglucinol derivatives from Garcinia oblongifolia.

Authors: Hamed W, Brajeul S, Mahuteau-Betzer F, Thoison O, Mons S, Delpech B, Nguyen VH, Sévenet T, Marazano C.

Abstract: Oblongifolins A-D (2-5), four new polyprenylated 3,4-dihydroxybenzoylphloroglucinol compounds, were isolated from the bark of Garcinia oblongifolia collected in Vietnam. The bark was also found to contain the known compounds camboginol and guttiferone B. Extraction of the leaves gave 2 and camboginol. Details of the structure elucidation of 2-5 and stereochemical comparisons with known natural derivatives of general formula 1a,b are presented. The biological activity of these compounds concerning interactions with tubulin was investigated.

CiteXplore: 16724839

DOI: 10.1021/np050543s