Document Report Card

ID: ALA1158037

Journal: J Nat Prod

Title: Taraxasterane- and ursane-type triterpenes from Nerium oleander and their biological activities.

Authors: Zhao M, Zhang S, Fu L, Li N, Bai J, Sakai J, Wang L, Tang W, Hasegawa T, Ogura H, Kataoka T, Oka S, Kiuch M, Hirose K, Ando M.

Abstract: Two new taraxasterane-type triterpenes, 20beta,28-epoxy-28alpha-methoxytaraxasteran-3beta-ol (1) and 20beta,28-epoxytaraxaster-21-en-3beta-ol (2), were isolated from an ethyl acetate extract of the leaves of Nerium oleander, together with ursane-type triterpenes, 28-nor-urs-12-ene-3beta,17beta-diol (3) and 3beta-hydroxyurs-12-en-28-aldehyde (4). The structures of 1 and 2 were established on the basis of their spectroscopic data. Anti-inflammatory activity of 1-4 was examined on the basis of inhibitory activity against the induction of intercellular adhesion molecule-1 (ICAM-1). Cytotoxic activity of 1-4 was evaluated against four human cell lines, A-549, WI-38, VA-13, and HepG2 cells.

CiteXplore: 16933868

DOI: 10.1021/np0680073