Document Report Card

ID: ALA1158086

Journal: J Nat Prod

Title: Phenolic marine natural products as aldose reductase inhibitors.

Authors: Manzanaro S, Salva J, de la Fuente JA.

Abstract: Four different types of marine natural compounds isolated from tunicates were found to inhibit human aldose reductase. They all are characterized by a heterocyclic system, and at least two phenolic groups are present in the structure. Two of the compounds tested showed an inhibitory potency 5/6-fold higher than that of the known AR inhibitor sorbinil. One notable structural feature of these active compounds is the lack of either the carboxylic acid or the spiro-hydantoin commonly present in the principal classes of currently used inhibitors.

CiteXplore: 17067167

DOI: 10.1021/np0503698