Document Report Card

ID: ALA1158089

Journal: J Nat Prod

Title: Indoleamine 2,3-dioxygenase inhibitors from the Northeastern Pacific Marine Hydroid Garveia annulata.

Authors: Pereira A, Vottero E, Roberge M, Mauk AG, Andersen RJ.

Abstract: Crude extracts of the marine hydroid Garveia annulata show potent inhibition of indoleamine 2,3-dioxygenase (IDO). Fractionation of the extract led to the identification of the new polyketides annulin C (1), 2-hydroxygarveatin E (4), garveatin E (5), and garvin C (9). Annulins A (2), B (3), and C (1) were found to be submicromolar inhibitors of IDO.

CiteXplore: 17067170

DOI: 10.1021/np060111x