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ID: ALA1158154
Journal: Bioorg Med Chem Lett
Title: Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitors.
Authors: Verissimo E, Berry N, Gibbons P, Cristiano ML, Rosenthal PJ, Gut J, Ward SA, O'Neill PM.
Abstract: The structure-based design, chemical synthesis and in vitro activity evaluation of various falcipain inhibitors derived from 2-pyridone are reported. These compounds contain a peptidomimetic binding determinant and a Michael acceptor terminal moiety capable of deactivating the cysteine protease active site.
CiteXplore: 18554905