Document Report Card

ID: ALA1158280

Journal: J Nat Prod

Title: Specific inhibition of human immunodeficiency virus type 1 reverse transcriptase mediated by soulattrolide, a coumarin isolated from the latex of calophyllum teysmannii.

Authors: Pengsuparp T, Serit M, Hughes SH, Soejarto DD, Pezzuto JM.

Abstract: Soulattrolide (1), a coumarin isolated from Calophyllum teysmannii latex, was found to be a potent inhibitor of HIV-1 reverse transcriptase (RT) with an IC50 of 0.34 microM. Inhibition was remarkably specific, with no appreciable activity being observed toward HIV-2 RT, AMV RT, RNA polymerase, or DNA polymerases alpha or beta.

CiteXplore: 8864237

DOI: 10.1021/np960399y