Document Report Card

ID: ALA1158290

Journal: J Nat Prod

Title: Two fungal lanostane derivatives as phospholipase A2 inhibitors.

Authors: Cuélla MJ, Giner RM, Recio MC, Just MJ, Máñez S, Ríos JL.

Abstract: The hydroalcoholic extract of Poria cocos and two lanostane derivatives isolated from it, pachymic acid (1) and dehydrotumulosic acid (2), were active as inhibitors of phospholipase A2 from snake venom when a polarographic method was used. Dehydrotumulosic acid exhibited an IC50 of 0.845 mM. These two compounds are structurally related to certain triterpenoids from Ganoderma and Schinus that have previously been described as competitive inhibitors of phospholipase A2. These comprise a new group of natural potential antiinflammatory agents due to their interaction with that enzyme.

CiteXplore: 8984162

DOI: 10.1021/np9604339