Basic Information
ID: ALA1158436
Journal: Bioorg Med Chem Lett
Title: In vitro inhibition of human erythrocyte glutathione reductase by some new organic nitrates.
Authors: Sentürk M, Talaz O, Ekinci D, Cavdar H, Küfrevioğlu OI.
Abstract: Glutathione reductase (GR), is responsible for the existence of GSH molecule, a crucial antioxidant against oxidative stress reagents. The antimalarial activities of some redox active compounds are attributed to their inhibition of antioxidant flavoenzyme glutathione reductase, and inhibitors are therefore expected to be useful for the treatment of malaria. Twelve organic nitrate derivatives were synthesized and treated with human erythrocyte GR. The molecules were identified as strong GR inhibitors and novel antimalaria candidates.
CiteXplore: 19447620
DOI: 10.1016/j.bmcl.2009.04.087
Patent ID: ┄
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