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ID: ALA1158447
Journal: Bioorg Med Chem Lett
Title: Substituted benzimidazoles: A novel chemotype for small molecule hKSP inhibitors.
Authors: Lahue BR, Ma Y, Shipps GW, Seghezzi W, Herbst R.
Abstract: Substituted benzimidazoles were profiled as inhibitors of kinesin spindle protein (KSP), an increasingly important target for the development of anticancer drugs. This series demonstrated the monoastral phenotypic response and was found to be active in both enzymatic and cellular-based assays.
CiteXplore: 19481450