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ID: ALA1158539
Journal: Bioorg Med Chem Lett
Title: Synthesis and biological activity of 2H-quinolizin-2-one based p38alpha MAP kinase inhibitors.
Authors: Tynebor RM, Chen MH, Natarajan SR, O'Neill EA, Thompson JE, Fitzgerald CE, O'Keefe SJ, Doherty JB.
Abstract: The development and synthesis of potent p38alpha MAP kinase inhibitors containing a 2H-quinolizin-2-one platform is described. Evolution of the 2H-quinolizin-2-one series from an early lead to solving off target activity and pharmacokinetic issues is also discussed.
CiteXplore: 20378346