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ID: ALA1158539

Journal: Bioorg Med Chem Lett

Title: Synthesis and biological activity of 2H-quinolizin-2-one based p38alpha MAP kinase inhibitors.

Authors: Tynebor RM, Chen MH, Natarajan SR, O'Neill EA, Thompson JE, Fitzgerald CE, O'Keefe SJ, Doherty JB.

Abstract: The development and synthesis of potent p38alpha MAP kinase inhibitors containing a 2H-quinolizin-2-one platform is described. Evolution of the 2H-quinolizin-2-one series from an early lead to solving off target activity and pharmacokinetic issues is also discussed.

CiteXplore: 20378346

DOI: 10.1016/j.bmcl.2010.03.069