Synthesis and biological evaluation of 1,4-diazepane derivatives as T-type calcium channel blockers.

ID: ALA1158564

Journal: Bioorg Med Chem Lett

Title: Synthesis and biological evaluation of 1,4-diazepane derivatives as T-type calcium channel blockers.

Authors: Gu SJ, Lee JK, Pae AN, Chung HJ, Rhim H, Han SY, Min SJ, Cho YS.

Abstract: We have synthesized and biologically evaluated 1,4-diazepane derivatives as T-type calcium channel blockers. In this study, we discovered compound 4s, a potential T-type calcium channel blocker with good selectivity over hERG and N-type calcium channels. In addition, it exhibited favorable pharmacokinetic characteristics for further investigation of T-type calcium channel related diseases.

CiteXplore: 20382529

DOI: 10.1016/j.bmcl.2010.03.084

Patent ID: ┄