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ID: ALA1158604
Journal: Bioorg Med Chem Lett
Title: New pyrazolo[1,5a]pyrimidines as orally active inhibitors of Lck.
Authors: Gommermann N, Buehlmayer P, von Matt A, Breitenstein W, Masuya K, Pirard B, Furet P, Cowan-Jacob SW, Weckbecker G.
Abstract: A novel series of pyrazolo[1,5a]pyrimidines was optimized to target lymphocyte-specific kinase (Lck). An efficient synthetic route was developed and SAR studies toward activity and selectivity are described, leading to Lck inhibitors with enzymatic, cellular and in vivo potency.
CiteXplore: 20483608