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ID: ALA1158618
Journal: Bioorg Med Chem Lett
Title: Two new asterosaponins, archasterosides A and B, from the Vietnamese starfish Archaster typicus and their anticancer properties.
Authors: Kicha AA, Ivanchina NV, Huong TT, Kalinovsky AI, Dmitrenok PS, Fedorov SN, Dyshlovoy SA, Long PQ, Stonik VA.
Abstract: New asterosaponins archasterosides A (1), B (2), and the known regularoside A (3) were isolated from the Vietnamese starfish Archaster typicus and structurally elucidated by extensive NMR techniques and chemical transformations. Compounds 1-3 showed moderate cytotoxic activities against HeLa and mouse JB6 P(+) Cl41 cell lines. The most active, 2, induced basal AP-1- and p53-, but not NF-kappaB-transcriptional activations in JB6 Cl41 cells.
CiteXplore: 20493687