Document Report Card

ID: ALA1158737

Journal: J Nat Prod

Title: The psammaplysenes, specific inhibitors of FOXO1a nuclear export.

Authors: Schroeder FC, Kau TR, Silver PA, Clardy J.

Abstract: A small collection of marine natural product extracts was screened for compounds that would compensate lost tumor suppressor functionality in PTEN-deficient cells. From the most active extract, the previously unreported bromotyrosine derivative, psammaplysene A (1), was identified. Psammaplysene A compensates for PTEN loss by relocalizing the transcription factor FOXO1a to the nucleus.

CiteXplore: 15844952

DOI: 10.1021/np049624z