Document Report Card

ID: ALA1158759

Journal: J Nat Prod

Title: Cytotoxic bisindole alkaloids from a marine sponge Spongosorites sp.

Authors: Bao B, Sun Q, Yao X, Hong J, Lee CO, Sim CJ, Im KS, Jung JH.

Abstract: Three new bisindole alkaloids of the hamacanthin class (1-3) and one new bisindole alkaloid of the topsentin class (6) were isolated along with known bisindole alkaloids (4, 5, 7-11) from the MeOH extract of a marine sponge Spongosorites sp. by bioactivity-guided fractionation. The planar structures were established on the basis of NMR, MS, and IR spectroscopic analyses. Configurations of compounds 1-4 were derived from 1H NMR data and optical rotation. Compounds 1, 4, 5, and 11 showed moderate to significant cytotoxicity against five human tumor cell lines, and compounds 1-5 showed weak antibacterial activity against clinically isolated methicillin-resistant strains.

CiteXplore: 15921415

DOI: 10.1021/np049577a