Document Report Card

ID: ALA1158806

Journal: J Nat Prod

Title: Cytotoxic activity of some natural and synthetic guaianolides.

Authors: Bruno M, Rosselli S, Maggio A, Raccuglia RA, Bastow KF, Lee KH.

Abstract: Several natural guaianolides and synthetic derivatives of repin (1) were tested and found to be active against tumor cell replication. Repin (1) and both mono- and di-halohydrin analogues (2, 7-9, 11, 12) showed significant antitumor potency. A more effective compound (17) was obtained by esterificating repin with the paclitaxel side chain.

CiteXplore: 16038545

DOI: 10.1021/np0500575