Extraction, hemisynthesis, and synthesis of canthin-6-one analogues. Evaluation of their antifungal activities.

ID: ALA1158823

Journal: J Nat Prod

Title: Extraction, hemisynthesis, and synthesis of canthin-6-one analogues. Evaluation of their antifungal activities.

Authors: Soriano-Agatón F, Lagoutte D, Poupon E, Roblot F, Fournet A, Gantier JC, Hocquemiller R.

Abstract: Zanthoxylum chiloperone var. angustifolium was investigated. Alkaloids 1-3 from the canthin-6-one series were characterized. Derivatives 7-28 were prepared by hemisynthesis or total synthesis. All compounds were tested for in vitro antifungal activities against five pathogenic fungal strains. Analogues of canthin-6-one did not show better antifungal activities.

CiteXplore: 16309303

DOI: 10.1021/np050250z

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