Document Report Card

ID: ALA1158842

Journal: J Nat Prod

Title: Antiproliferative triterpene saponins from Entada africana.

Authors: Cioffi G, Dal Piaz F, De Caprariis P, Sanogo R, Marzocco S, Autore G, De Tommasi N.

Abstract: Nine new ester saponins (1-9) were isolated from the roots of Entada africana. Their structures were elucidated by 1D and 2D NMR experiments including 1D and 2D TOCSY, DQF-COSY, HSQC, and HMBC spectroscopy, as well as ESIMS analysis, and chemical methods. The aglycon moieties were found to be echinocystic acid for compounds 1, 2, 4-6, 8, and 9 and acacic acid for 3 and 7. All isolated compounds were tested for their antiproliferative activity against the J774.A1, HEK-293, and WEHI-164 cell lines. Moderate to high cytotoxic potency was found for almost all compounds tested.

CiteXplore: 16989528

DOI: 10.1021/np060257w