Document Report Card

ID: ALA1158861

Journal: J Nat Prod

Title: Zanhasaponins A and B, antiphospholipase A2 saponins from an antiinflammatory extract of Zanha africana root bark.

Authors: Cuéllar MJ, Giner RM, Recio MC, Just MJ, Máñez S, Cerdá M, Hostettmann K, Ríos JL.

Abstract: A MeOH extract from Z. africana was examined for topical antiinflammatory activity and proved to be active against arachidonic acid (AA) acute edema, 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced chronic inflammation, and oxazolone delayed-type hypersensitivity in mice. The extract also showed significant inhibitory activity of Naja naja phospholipase A2 when a polarographic method was used. Two oleanane-type triterpene saponins, zanhasaponins A (1) and B (2), and the cyclitol pinitol (4), isolated from the extract, were active as inhibitors of PLA2. A further saponin, zanhasaponin C (3) was inactive in this assay.

CiteXplore: 9392883

DOI: 10.1021/np970221r