Document Report Card

ID: ALA1158956

Journal: J Nat Prod

Title: Biologically active metabolites from Xenorhabdus spp., Part 2. Benzopyran-1-one derivatives with gastroprotective activity.

Authors: McInerney BV, Taylor WC, Lacey MJ, Akhurst RJ, Gregson RP.

Abstract: Two novel antibiotic compounds, named xenocoumacins 1 [2] and 2 [3], with potent antiulcer activity were isolated from cultures of Xenorhabdus spp. Both compounds exhibit antibacterial activity and potent antiulcer activity against stress-induced ulcers when dosed orally. In addition, 2 has antifungal activity. Their chemical structures were determined by extensive 1H-nmr, 13C-nmr, and mass spectral studies to be 3,4-dihydro-8-hydroxy-1H-2-benzopyran-1-one derivatives.

CiteXplore: 1955881

DOI: 10.1021/np50075a006