Document Report Card

ID: ALA1159026

Journal: J Nat Prod

Title: Brominated beta-carbolines from the marine tunicate Eudistoma album.

Authors: Adesanya SA, Chbani M, Païs M, Debitus C.

Abstract: Chemical investigation of the cytotoxic EtOH extract of the marine tunicate Eudistoma album led to the isolation of three brominated beta-carbolines which were characterized by their spectral data. Two of them, eudistomin E, which is already known for its potent antiviral activity, and the novel compound eudistalbin A [1], were shown to possess cytotoxic activity (ED50 less than 5.0 ng and 3.2 micrograms/ml respectively) in vitro against the growth of KB human buccal carcinoma cells. The third compound, eudistalbin B [2], is a new inactive natural product.

CiteXplore: 1512602

DOI: 10.1021/np50082a025