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ID: ALA1159074
Journal: Bioorg Med Chem
Title: Inhibitory effect of novel tetrahydropyrimidine-2(1H)-thiones on melanogenesis.
Authors: Thanigaimalai P, Lee KC, Bang SC, Lee JH, Yun CY, Roh E, Hwang BY, Kim Y, Jung SH.
Abstract: The series of imidazoldine-2-thiones 2 and tetrahydropyrimidine-2-thiones 3 were discovered as inhibitor of alpha-MSH-induced melanin production in melanoma B16 cells. The primary bioassay showed that 1-(4-ethylbenzyl)-tetrahydropyrimidine-2(1H)-thione 3e (>100% inhibition at 10 microM, IC(50)=1.2 microM) and 1-(4-tert-butylbenzyl)-tetrahydropyrimidine-2(1H)-thione 3f (>100% inhibition at 10 microM, IC(50)=0.76 microM) exhibited potent inhibitory effect against alpha-MSH-induced melanin production. Compounds 3 inhibit the biosynthesis of tyrosinase without affecting its catalytic activity in melanogenesis.
CiteXplore: 20044259