Document Report Card

ID: ALA1159199

Journal: J Nat Prod

Title: A new antiplatelet diarylheptanoid from Alpinia blepharocalyx.

Authors: Doug H, Chen SX, Xu HX, Kadota S, Namba T.

Abstract: A new diarylheptanoid, 1,7-bis(4-hydroxyphenyl)-3-hydroxy-1,3-heptadien-5-one (1), along with seven other known compounds, were isolated from the seeds of Alpinia blepharocalyx. Of these, compounds 1 and 3 showed strong inhibition of collagen-induced, arachidonic acid-induced, and adenosine diphosphate-induced platelet aggregation of human whole blood. Compound 3 also strongly inhibited ristocetin-induced platelet aggregation. Structures of these compounds were elucidated by spectroscopic and chemical means.

CiteXplore: 9461664

DOI: 10.1021/np970293i