Document Report Card

ID: ALA1159203

Journal: J Nat Prod

Title: Agelastatins C and D, new pentacyclic bromopyrroles from the sponge Cymbastela sp., and potent arthropod toxicity of (-)-agelastatin A.

Authors: Hong TW, Jímenez DR, Molinski TF.

Abstract: Two new agelastatins, C (3) and D (4), along with the known compound (-)-agelastatin A (1), were isolated from the Indian Ocean sponge Cymbastela sp. The structures were determined by analysis of spectroscopic data and chemical correlation of 4 with a common derivative 5, also prepared from 1. Agelastatin A (1) exhibited potent activity against brine shrimp (LC50 1.7 ppm) in addition to insecticidal activity against larvae of beet army worm, Spodoptera exigua, and corn rootworm, Diabrotica undecimpunctata.

CiteXplore: 9461668

DOI: 10.1021/np9703813