Document Report Card

ID: ALA1159214

Journal: J Nat Prod

Title: The antiallergic activities of synthetic acrophylline and acrophyllidine.

Authors: Huang AC, Lin TP, Kuo SC, Wang JP.

Abstract: The antiallergic activities of synthetic acrophylline [1] and acrophyllidine [2] have been demonstrated. Both compounds 1 and 2 at 30 mumol/kg reduced the plasma leakage in mouse ear in a passive cutaneous anaphylactic (PCA) reaction. In addition, compound 1 suppressed mast cell degranulation in a dose-dependent manner, while compound 2 at 100 microM produced no significant inhibition of the release of preformed inflammatory mediators. These results suggest that the antiallergic effect of compound 1 probably occurs through the suppression of mast cell degranulation, and that of compound 2 by protection of the vasculature against challenge by mediators of inflammation.

CiteXplore: 7760067

DOI: 10.1021/np50115a016