Document Report Card

ID: ALA1159309

Journal: J Nat Prod

Title: A prolyl endopeptidase-inhibiting benzofuran dimer from Polyozellus multiflex.

Authors: Song KS, Raskin I.

Abstract: A new benzofuran dimer, 5,6,5',6'-tetrahydroxy[3,3']bibenzofuranyl-2,2'-dicarboxylic acid dimethyl ester (kynapcin-24), was isolated from Polyozellus multiflex and shown to noncompetitively inhibit prolyl endopeptidase (PEP), with an IC(50) value of 1.14 microM. Kynapcin-24 was less inhibitory to other serine proteases such as chymotrypsin, trypsin, and elastase.

CiteXplore: 11809072

DOI: 10.1021/np010194b