Document Report Card

ID: ALA1159311

Journal: J Nat Prod

Title: Antiinflammatory constituents of Celastrus orbiculatus inhibit the NF-kappaB activation and NO production.

Authors: Jin HZ, Hwang BY, Kim HS, Lee JH, Kim YH, Lee JJ.

Abstract: Two new sesquiterpene esters, 1beta,8beta-diacetoxyl-6alpha,9alpha-difuroyloxydihydro-beta-agarofuran (1) and 1beta-acetoxyl-2beta,6alpha,9alpha-trifuroyloxydihydro-beta-agarofuran (2), together with four known sesquiterpene esters (3-6), celastrol (7), and celaphanol A (8) were isolated from the roots of Celastrus orbiculatus in a search for inhibitors of NF-kappaB activation and nitric oxide production. Compound 7 was the most active, while compounds 1, 2, 4, and 8 showed moderate inhibition in both NF-kappaB activation and nitric oxide production.

CiteXplore: 11809076

DOI: 10.1021/np010428r