Document Report Card

ID: ALA1159325

Journal: J Nat Prod

Title: Pseudoirroratin A, a new cytotoxic ent-kaurene diterpene from Isodon pseudo-irrorata.

Authors: Zhang H, Fan Z, Tan GT, Chai HB, Pezzuto JM, Sun H, Fong HH.

Abstract: A new ent-kaurene diterpene, pseudoirroratin A (1), and a known diterpene, pseurata A, were isolated from Isodon pseudo-irrorata. Compound 1 showed significant cytotoxicity against the Lu1, SW626, LNCaP, KB, and HOS cancer cell lines with IC(50) values of 0.26 (0.75), 0.20 (0.57), 0.90 (2.59), 0.90 (2.59), and 0.50 (1.44) microg/mL (microM), respectively. The structure of 1 was elucidated by spectroscopic means including 1D and 2D NMR techniques.

CiteXplore: 11858760

DOI: 10.1021/np010420h