Document Report Card

ID: ALA1165957

Journal: J Nat Prod

Title: Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents.

Authors: Costa EV, Pinheiro ML, Barison A, Campos FR, Salvador MJ, Maia BH, Cabral EC, Eberlin MN.

Abstract: Phytochemical investigation of the bark of Guatteria hispida afforded three new alkaloids, 9-methoxy-O-methylmoschatoline (1), 9-methoxyisomoschatoline (2), and isocerasonine (3), along with 10 known alkaloids, 8-oxopseudopalmatine (4), O-methylmoschatoline (5), lysicamine (6), liriodenine (7), 10-methoxyliriodenine (8), nornuciferine (9), anonaine (10), xylopine (11), coreximine (12), and isocoreximine (13). The major compounds, 2, 6, 12, and 13, showed significant antioxidant capacity in the ORAC(FL) assay. Compounds 5, 6, and 7 were active against S. epidermidis and C. dubliniensis, with MIC values in the range 12.5-100 microg mL(-1).

CiteXplore: 20476748

DOI: 10.1021/np100013r