Bacterial transferase MraY inhibitors: synthesis and biological evaluation.

Basic Information

ID: ALA1166006

Journal: Bioorg Med Chem

Title: Bacterial transferase MraY inhibitors: synthesis and biological evaluation.

Authors: Lecerclé D, Clouet A, Al-Dabbagh B, Crouvoisier M, Bouhss A, Gravier-Pelletier C, Le Merrer Y.

Abstract: New inhibitors of the bacterial transferase MraY are described. Their structure is based on an aminoribosyl-O-uridine like scaffold, readily obtained in two key steps. The amino group can be coupled with proline or guanylated. Alternatively, these amino, prolinyl or guanidinyl groups can be introduced through a triazole linker. Biological evaluation of these compounds on MraY from Bacillus subtilis revealed interesting inhibitory activity for both amino compounds.

CiteXplore: 20537545

DOI: 10.1016/j.bmc.2010.04.023

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