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ID: ALA1177646
Journal: Bioorg Med Chem
Title: Inhibition of prolyl oligopeptidase with a synthetic unnatural dipeptide.
Authors: Racys DT, Rea D, Fülöp V, Wills M.
Abstract: A new inhibitor, containing a linked proline-piperidine structure, for the enzyme prolyl oligopeptidase (POP) has been synthesised and demonstrated to bind covalently with the enzyme at the active site. This provides evidence that covalent inhibitors of POP do not have to be limited to structures containing five-membered N-containing heterocyclic rings.
CiteXplore: 20627594